Andersen, Ida Vang published the artcileOptimization of Direct Aromatic 18F-Labeling of Tetrazines, Recommanded Product: Tetraethylammonium hydrogencarbonate, the publication is Molecules (2022), 27(13), 4022, database is CAplus and MEDLINE.
Radiolabeling of tetrazines has gained increasing attention due to their important role in pretargeted imaging or therapy. The most commonly used radionuclide in PET imaging is fluorine-18. For this reason, we have recently developed a method which enables the direct aromatic 18F-fluorination of tetrazines using stannane precursors through copper-mediated fluorinations. Herein, we further optimized this labeling procedure. 3-(3-fluorophenyl)-1,2,4,5-tetrazine was chosen for this purpose because of its high reactivity and resp. limited stability during the labeling process. By optimizing parameters such as elution conditions, precursor amount, catalyst, time or temperature, the radiochem. yield (RCY) could be increased by approx. 30%. These conditions were then applied to optimize the RCY of a recently successfully developed and promising pretargeting imaging agent. This agent could be isolated in a decay corrected RCY of 14 ¡À 3% and Am of 201 ¡À 30 GBq/¦Ìmol in a synthesis time of 70 min. Consequently, the RCY increased by 27%.
Molecules published new progress about 17351-61-0. 17351-61-0 belongs to catalysis-chemistry, auxiliary class Phase Transfer Catalyst, name is Tetraethylammonium hydrogencarbonate, and the molecular formula is C9H21NO3, Recommanded Product: Tetraethylammonium hydrogencarbonate.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia