Athavale, Soumitra V. published the artcileBiocatalytic, Intermolecular C-H Bond Functionalization for the Synthesis of Enantioenriched Amides, Synthetic Route of 1293990-73-4, the publication is Angewandte Chemie, International Edition (2021), 60(47), 24864-24869, database is CAplus and MEDLINE.
Directed evolution of heme proteins has opened access to new-to-nature enzymic activity that can be harnessed to tackle synthetic challenges. Among these, reactions resulting from active site iron-nitrenoid intermediates present a powerful strategy to forge C-N bonds with high site- and stereoselectivity. Here authors report a biocatalytic, intermol. benzylic C-H amidation reaction operating at mild and scalable conditions. With hydroxamate esters as nitrene precursors, feedstock aromatic compounds can be converted to chiral amides with excellent enantioselectivity (up to >99% ee) and high yields (up to 87%). Kinetic and computational anal. of the enzymic reaction reveals rate-determining nitrenoid formation followed by stepwise hydrogen atom transfer-mediated C-H functionalization.
Angewandte Chemie, International Edition published new progress about 1293990-73-4. 1293990-73-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is O-Pivaloylhydroxylamine trifluoromethanesulfonate, and the molecular formula is C6H12F3NO5S, Synthetic Route of 1293990-73-4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia