Chaudhuri, Dipankar published the artcileChemical synthesis of a potent antimicrobial peptide Murepavadin using a tandem native chemical ligation/desulfurization reaction, COA of Formula: C20H19NO4, the publication is Journal of Organic Chemistry (2021), 86(21), 15242-15246, database is CAplus and MEDLINE.
Classical approaches for the backbone cyclization of polypeptides require conditions that may compromise the chirality of the C-terminal residue during the activation step of the cyclization reaction. Here, we describe an efficient epimerization-free approach for the Fmoc-based (Fmoc = 9-fluorenyl-methoxycarbonyl) synthesis of murepavadin using intramol. native chem. ligation in combination with a concomitant desulfurization reaction. Using this approach, bioactive murepavadin was produced in a good yield in two steps. The synthetic peptide antibiotic showed potent activity against different clin. isolates of P. aeruginosa. This approach can be easily adapted for the production of murepavadin analogs and other backbone-cyclized peptides.
Journal of Organic Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, COA of Formula: C20H19NO4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia