Datta, Sanchita published the artcileSynthesis, anticancer activity, SAR and binding mode of interaction studies of substituted pentanoic acids: part II, Name: 4-Nitrophenylacetic acid, the publication is Future Medicinal Chemistry (2022), 14(1), 17-34, database is CAplus and MEDLINE.
Here, 13 new compounds were synthesized and characterized. Along with these new compounds, 16 previously reported phenyl/naphthylacetyl pentanoic acid derivatives were biol. evaluated. Compounds I and II showed good cytotoxicity against leukemia cell line Jurkat E6.1. The mechanisms of cytotoxicity of these compounds were confirmed by DNA deformation assay and reactive oxygen species assay. MMP-2 and HDAC8 expression assays suggested the dual inhibiting property of these two compounds These findings were supported by results of mol. docking studies. In silico pharmacokinetic properties showed compounds I and II have high gastrointestinal absorption. This study highlights the action of phenyl/naphthylacetyl pentanoic acid derivatives as anticancer agents.
Future Medicinal Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Name: 4-Nitrophenylacetic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia