Goess, Brian C. published the artcileSynthesis of a 10,000-Membered Library of Molecules Resembling Carpanone and Discovery of Vesicular Traffic Inhibitors, Formula: C10H25NO2Si, the publication is Journal of the American Chemical Society (2006), 128(16), 5391-5403, database is CAplus and MEDLINE.
Split-and-pool synthesis of a 10,000-membered library of mols. resembling the natural product carpanone has been achieved. The synthesis features development of solid-phase multicomponent reactions between nitrogen nucleophiles, enones, and hydroxylamines, and a solid-phase application of the Huisgen cycloaddition affording substituted triazoles. The synthesis was performed in high-capacity (500 ¦Ìm) polystyrene beads using a one bead-one stock solution strategy that enabled phenotypic screens of the resulting library. Using whole-cell fluorescence imaging, we discovered a series of mols. from the carpanone-based library that inhibit exocytosis from the Golgi apparatus The most potent member of this series (I; CLL-19) has an IC50 of 14 ¦ÌM. We also report structure-activity relationships for the mols. exhibiting this interesting phenotype. These inhibitors of exocytosis may be useful reagents for the study of vesicular traffic.
Journal of the American Chemical Society published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C10H25NO2Si, Formula: C10H25NO2Si.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia