Heitel, Pascal published the artcileComputer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype, Synthetic Route of 31719-76-3, the publication is ACS Medicinal Chemistry Letters (2019), 10(2), 203-208, database is CAplus and MEDLINE.
As universal heterodimer partners of many nuclear receptors, the retinoid X receptors (RXRs) constitute key transcription factors. They regulate cell proliferation, differentiation, inflammation, and metabolic homeostasis and have recently been proposed as potential drug targets for neurodegenerative and inflammatory diseases. Owing to the hydrophobic nature of RXR ligand binding sites, available synthetic RXR ligands are lipophilic, and their structural diversity is limited. Here, we disclose the computer-assisted discovery of a novel RXR agonist chemotype and its systematic optimization toward potent RXR modulators. We have developed a nanomolar RXR agonist with high selectivity among nuclear receptors and superior physicochem. properties compared to classical rexinoids that appears suitable for in vivo applications and as lead for future RXR-targeting medicinal chem.
ACS Medicinal Chemistry Letters published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H12O3, Synthetic Route of 31719-76-3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia