Moldovan, Rares-Petru published the artcileDesign, radiosynthesis and preliminary biological evaluation in mice of a brain-penetrant 18F-Labelled ¦Ò2 receptor ligand, Formula: C17H37NO3, the publication is International Journal of Molecular Sciences (2021), 22(11), 5447, database is CAplus and MEDLINE.
The ¦Ò2 receptor (transmembrane protein 97), which is involved in cholesterol homeostasis, is of high relevance for neoplastic processes. The upregulated expression of ¦Ò2 receptors in cancer cells and tissue in combination with the antiproliferative potency of ¦Ò2 receptor ligands motivates the research in the field of ¦Ò2 receptors for the diagnosis and therapy of different types of cancer. Starting from the well described 2-(4-(1H-indol-1-yl)butyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline class of compounds, we synthesized a novel series of fluorinated derivatives bearing the F-atom at the aromatic indole/azaindole subunit. RM273 (2-[4-(6-fluoro-1H-pyrrolo[2,3-b]pyridin-1-yl)butyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline) was selected for labeling with 18F and evaluation regarding detection of ¦Ò2 receptors in the brain by positron emission tomog. Initial metabolism and biodistribution studies of [18F]RM273 in healthy mice revealed promising penetration of the radioligand into the brain. Preliminary in vitro autoradiog. on brain cryosections of an orthotopic rat glioblastoma model proved the potential of the radioligand to detect the upregulation of ¦Ò2 receptors in glioblastoma cells compared to healthy brain tissue. The results indicate that the herein developed ¦Ò2 receptor ligand [18F]RM273 has potential to assess by non-invasive mol. imaging the correlation between the availability of ¦Ò2 receptors and properties of brain tumors such as tumor proliferation or resistance towards particular therapies.
International Journal of Molecular Sciences published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Formula: C17H37NO3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia