Narode, Hanuman published the artcileVanillin containing 9H-fluoren sulfone scaffolds: Synthesis, biological evaluation and molecular docking study, Product Details of C20H19NO4, the publication is Results in Chemistry (2022), 100269, database is CAplus.
Vanillin containing 9H-fluoren sulfone scaffolds I [R = Fmoc-Gly, Fmoc-Pro, Fmoc-Phe, etc.] were prepared by coupling a sulfone amine with carboxylic acid group of amino acids in presence of peptide coupling reagent hexafluorophosphate benzotriazole tetra-Me uronium (HBTU). All eight compounds I synthesized vanillin containing 9H-fluoren sulfone scaffolds were evaluated for their biol. activities, namely, antibacterial, antifungal and antimalarial. The antibacterial evaluation revealed that compounds I [R = Fmoc-Ala, Fmoc-Ser(t-Bu), Fmoc-Pro, Fmoc-Leu, Fmoc-D-Val, Fmoc-Met] exhibited potency against tested pathogenic bacteria, especially against Staphylococcus aureus. Compounds I [R = Fmoc-Ala, Fmoc-Val, Fmoc-Phe] manifested considerable antifungal activities against Candida albicans, Aspergillus niger and A. clavatus. Moreover, the antimalarial result demonstrated excellent antimalarial activities for compounds I [R = Fmoc-Ala, Fmoc-Val] against Plasmodium falciparum with IC50 less than the standard quinine. Further, mol. docking study was performed to find mol. level interaction of compounds with malarial drug target enzyme P. falciparum dihydrofolate reductase-thymidylate synthase (pfdher-ts). Interestingly, for all tested sulfone scaffolds the docking energy was found between -8.6 to -10.6 kcal/mol, which was higher than both of the standard drugs’ (quinine and chloroquine) docking energy, i.e. -8.4 and -6.9, resp. The results of this study confirmed the importance of the sulfone class of compounds in the treatment of parasitic infections and microbial infections.
Results in Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Product Details of C20H19NO4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia