Nishimine, Takayuki published the artcileKinetic Resolution of Allyl Fluorides by Enantioselective Allylic Trifluoromethylation Based on Silicon-Assisted C-F Bond Cleavage, Synthetic Route of 1206-46-8, the publication is Angewandte Chemie, International Edition (2014), 53(2), 517-520, database is CAplus and MEDLINE.
Under optimized reaction conditions, the synthesis of the target compounds was achieved by a reaction of trimethyl(trifluoromethyl)silane with Morita-Baylis-Hillman-reaction products [¦Â-fluoro-¦Á-(methylene)benzenepropanoic acid ester derivatives] using (9S)-(9”S)-9,9”-[1,4-phthalazinediylbis(oxy)]bis[10,11-dihydro-6′-methoxycinchonan] [i.e., (DHQD)2PHAL] as catalyst. The products thus formed included (¦ÂS)-¦Á-methylene-¦Â-(trifluoromethyl)benzenepropanoic acid Me ester (I), (¦ÂR)-¦Á-methylene-¦Â-(trifluoromethyl)benzenepropanoic acid Me ester and (¦ÂR)-¦Â-fluoro-¦Á-(methylene)benzenepropanoic acid Me ester, (¦ÂS)-¦Â-fluoro-¦Á-(methylene)benzenepropanoic acid Me ester. The corresponding enantiomers were obtained using (9S,9”S)-9,9”-[(2,5-diphenyl-4,6-pyrimidinediyl)bis(oxy)]bis[10,11-dihydro-6′-methoxycinchonan] [(DHQD)2PYR] as catalyst.
Angewandte Chemie, International Edition published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Synthetic Route of 1206-46-8.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia