Popiol, Justyna published the artcileThe involvement of xanthone and (E)-cinnamoyl chromophores for the design and synthesis of novel sunscreening agents, Related Products of catalysis-chemistry, the publication is International Journal of Molecular Sciences (2021), 22(1), 34, database is CAplus and MEDLINE.
In this study, seventeen novel mols. I [R1 = H, 6-MeO, 7-Cl; R2 = ([3-(2-chlorophenyl)prop-2-enoyl]oxy)methyl, ([3-phenylprop-2-enoyl]oxy)methyl, (3-([3-(4-methoxyphenyl)prop-2-enoyl]oxy)propoxy)methyl, etc.] by combining in the structures two chromophores: xanthone and (E)-cinnamoyl moiety were designed and synthesized. The UV spectroscopic properties of the tested compounds I were confirmed in chloroform solutions They acted as UVB or UVA/UVB absorbers. The most promising compound I [R1 = 6-MeO, R2 = ([3-(2,4-dimethoxyphenyl)prop-2-enoyl]oxy)methyl] absorbed UV radiation in the range 290-369 nm. Its photoprotective activity and functional photostability were further evaluated after wet milling and incorporation in the cream base. This tested formulation with compound I [R1 = 6-MeO, R2 = ([3-(2,4-dimethoxyphenyl)prop-2-enoyl]oxy)methyl] possessed very beneficial UV protection parameters (SPFin vitro of 19.69 ¡À 0.46 and UVA PF of 12.64 ¡À 0.32) which were similar as broad-spectrum UV filter tris-biphenyl triazine. Addnl., compound I [R1 = 6-MeO, R2 = ([3-(2,4-dimethoxyphenyl)prop-2-enoyl]oxy)methyl] was characterized by high values of critical wavelength (381 nm) and UVA/UVB ratio (0.830) thus it was a good candidate for broad-spectrum UV filter and it might protect skin against UVA-induced photoaging. Compound I [R1 = 6-MeO, R2 = ([3-(2,4-dimethoxyphenyl)prop-2-enoyl]oxy)methyl] were also shown to be photostable, non-cytotoxic at concentrations up to 50¦ÌM when tested on five cell lines and non-mutagenic in Ames test. It also possessed no estrogenic activity, according to the results of MCF-7 breast cancer model. Addnl., its favorable lipophilicity (miLogP = 5.62) does not predispose it to penetrate across the skin after topical application.
International Journal of Molecular Sciences published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Related Products of catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia