Shimizu, Norikazu published the artcileAge-related copper, zinc, and iron metabolism in Long-Evans cinnamon rats and copper-eliminating effects of D-penicillamine and trienthine-2HCl, Name: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Journal of Trace Elements in Experimental Medicine (1997), 10(2), 49-59, database is CAplus.
The Long-Evans cinnamon (LEC) rat is an animal model of human Wilson’s disease. The hepatic copper content of LEC rats increased in an age-dependent manner from 4-5 days of age and was maintained at a high level from 15-16 wk of age. The renal copper content of LEC rats showed a tendency to increase from 10 wk of age and increased rapidly from 15 wk of age. No difference in whole-brain copper concentration was observed between LEC and Long-Evans agouti (LEA) rats. LEC rats treated with D-penicillamine and trienthine-2HCl had reduced liver dysfunction. These agents reduced the hepatic copper content by ?1/2-2/3 and the renal copper content to within the normal range. They also decreased the copper content of hair and nails, and there was also a good correlation between the copper content of liver and white hair.
Journal of Trace Elements in Experimental Medicine published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C10H14BNO3, Name: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia