Smith, Samuel M. published the artcileScope, Limitations and Mechanistic Analysis of the HyperBTM-Catalyzed Acylative Kinetic Resolution of Tertiary Heterocyclic Alcohols, SDS of cas: 104-03-0, the publication is European Journal of Organic Chemistry (2022), 2022(1), e202101111, database is CAplus.
The full scope and limitations of the catalytic acylative kinetic resolution of a range of tertiary heterocyclic alcs. (78 examples, s up to >200) is reported under operationally-simple conditions, using low loadings of a com. available Lewis basic isothiourea catalyst, HyperBTM (generally 1 mol %). The protocol is highly effective for the kinetic resolution of 3-substituted 3-hydroxyoxindole and ¦Á-substituted ¦Á-hydroxylactam derivatives bearing up to three potential recognition motifs at the stereogenic tertiary carbinol center. The full power of this methodol. has been showcased through the synthesis of highly enantioenriched biol.-active target compounds in both enantiomeric forms. To provide further insight into the reaction mechanism, a detailed kinetic anal. of this Lewis base-catalyzed acylation of tertiary alcs. is reported using the variable time normalization anal. (VTNA) method.
European Journal of Organic Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C15H23BO2, SDS of cas: 104-03-0.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia