Spino, Claude published the artcileA Chiral Cyclohexanone Linked to Polystyrene for Solid-Phase Synthesis of Chiral ¦Á-Carbonyls, Recommanded Product: 2-Methyl-4-phenylbutanoic acid, the publication is Journal of Combinatorial Chemistry (2005), 7(2), 345-352, database is CAplus and MEDLINE.
Two chiral cyclohexanones were linked to polystyrene resin. The polymer-bound auxiliaries were subjected to a sequence of four reactions, the last of which cleaves the desired ¦Á-chiral carbonyl compound off the resin, concurrently regenerating the resin-bound auxiliary in its original form. Thus, addition of vinyllithiums, derived from alkenyl iodides R1CH2CH2CH:CHI (R1 = n-Pr, Ph, Me3CSiMe2O), to the resin-bound cyclohexanone I (X = resin) followed by chloroformylation / cuprate addition gave the resin-bound alkylidenecyclohexanes II (R2 = Me, Me3C, Ph, 1-naphthyl, etc.), which were cleaved by ozonation to give, after reduction of oxidation if required, a set of non-racemic alcs., aldehydes and carboxylic acids ZCHR2CH2CH2R1 (Z = HOCH2, CHO, HO2C). The resin can then be reused.
Journal of Combinatorial Chemistry published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C13H9FO, Recommanded Product: 2-Methyl-4-phenylbutanoic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia