Xu, Zhongrong published the artcileTunable Trifunctionalization of Tertiary Enaminones for the Regioselective and Metal-Free Synthesis of Discrete and Proximal Phosphoryl Nitriles, Application In Synthesis of 2051-95-8, the publication is Organic Letters (2021), 23(13), 5049-5053, database is CAplus and MEDLINE.
Tertiary keto enamines RCOCH:CHNMe2 undergo organocatalytic regiodivergent addition with secondary phosphine oxides Ar2P(O)H, giving phosphinyl ketonitriles RCOCH(POAr2)CH2CN (4) or RCOCH2CH(CN)P(O)Ar2 (5) depending on the catalyst, either Bu4NOH or AcOH, resp. This paper reports an unprecedented trifunctionalization of tertiary enaminones for the synthesis phosphoryl nitriles by the reactions of enaminones with diarylphosphine oxides and trimethylsilyl cyanide (TMSCN) without the use of any metal reagent. Employing tetra-Bu ammonium hydroxide (TBAH) as the catalyst (0.2 equiv) enables discrete cyanophosphonation, giving ¦Â-phosphinyl nitriles 4. On the other hand, selective proximal cyanophosphonation, yielding ¦Á-phosphinyl nitriles 5, has been realized in the presence of acetic acid only (AcOH).
Organic Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H11NO4, Application In Synthesis of 2051-95-8.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia