Bevers, Susan published the artcilePerylene- and Naphthalene-Based Linkers for Duplex and Triplex Stabilization, Application In Synthesis of 215297-17-9, the publication is Journal of the American Chemical Society (1998), 120(42), 11004-11005, database is CAplus.
Perylene and naphthalene were chosen for development into planar ¦Ð-stacking linkers in DNA duplex or triplex preparations Linkers were prepared by reaction of the corresponding tetra-carboxylic acid dianhydride with 2-aminoethoxyethanol or its tBDMS derivative Thermal stabilities of DNA duplex (5′-TCTTTTCTT-linker-AAGAAAAGA) or triplex (5′-TCTTTTCTT-linker-TTCTTTTCT/9-mer or 19-mer) systems. Both the perylene and naphthalene-based duplex linkers showed increased TM values, compared to a duplex tethered by hexa(ethylene glycol), but the perylene linker showed only a small increase over naphthalene, perhaps because it is significantly larger than necessary to bridge the phosphate residues at the terminus of a B-form helix, while the naphthalene-based linker can be more optimally positioned at the end of a duplex. In triplex formation, the most significant TM enhancements were those that occurred with the 19-mer complex, where the perylene-based linker showed a 19¡ã increase at pH 5.5; for both linkers, this is perhaps due to their potential to provide stacking interactions with all three residues, and possibly with the first base residue of the target strand that extends beyond the triplex region.
Journal of the American Chemical Society published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C10H25NO2Si, Application In Synthesis of 215297-17-9.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia