Dowlati, Bahram published the artcileA combination risk assessment of paracetamol: electrochemical oxidation behavior and cytotoxic effect evaluation of paracetamol in the presence of N1,N2-dibenzylethane-1,2-diamine, Related Products of catalysis-chemistry, the publication is New Journal of Chemistry (2016), 40(6), 5121-5127, database is CAplus.
The cytotoxic effect of paracetamol in the presence of a diamine derivative was evaluated in liver cells. In this study, hydropyrazinoquinoxalinylidene-acetamide (HPQA), as an agent that is toxic to the liver, was synthesized in an electrochem. cell as a simulated body environment by an electrooxidation reaction. A direct electron transfer (DET) mechanism occurred during the process on the surface of the carbon anode. The electrochem. oxidation of paracetamol was studied using cyclic voltammetry and controlled-potential coulometry (CPC) techniques. The product was characterized by FT-IR, 1H NMR, 13C NMR and ESI-MS2 after purification The cytotoxicity of the final compound was evaluated using an MTT assay on the CCL-13 liver cell line. The results indicate that the presence of amine derivatives leads to an increase in the toxic effects of paracetamol in the human body. The cell viability at a concentration of 500 ¦Ìg mL-1 was 78% for paracetamol, whereas the viability of liver cells in the presence of the product was 18% at 168 ¦Ìg mL-1. A cycloaddition mechanism was suggested according to the overall results that were obtained.
New Journal of Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Related Products of catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia