Eibl, Christoph published the artcileThe 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: Carboxamide derivatives with different spacer motifs, Product Details of C9H7NO4, the publication is Bioorganic & Medicinal Chemistry (2013), 21(23), 7309-7329, database is CAplus and MEDLINE.
3,7-Diazabicyclo[3.3.1]nonane (bispidine) based nicotinic acetylcholine receptor (nAChR) ligands, e.g., I, have been synthesized and evaluated for nAChRs interaction. Diverse spacer motifs were incorporated between the hydrogen bond acceptor (HBA) part and a variety of substituted (hetero)aryl moieties. Bispidine carboxamides bearing spacer motifs often showed high affinity in the low nanomolar range and selectivity for the ¦Á4¦Â2* nAChR. Compound I and the other two tested compounds with Ki values of about 1 nM displayed the highest affinities for ¦Á4¦Â2* nAChR. All evaluated compounds are partial agonists or antagonists at ¦Á4¦Â2*, with reduced or no effects on ¦Á3¦Â4* with the exception of compound I (agonist), and reduced or no effect at ¦Á7 and muscle subtypes.
Bioorganic & Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Product Details of C9H7NO4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia