Hong, Seung Youn published the artcileSelective formation of ¦Ã-lactams via C-H amidation enabled by tailored iridium catalysts, Name: 2-Methyl-4-phenylbutanoic acid, the publication is Science (Washington, DC, United States) (2018), 359(6379), 1016-1021, database is CAplus and MEDLINE.
Intramol. insertion of metal nitrenes into C-H bonds to form ¦Ã-lactam rings has traditionally been hindered by competing isocyanate formation. The application of theory and mechanism studies to optimize a class of Ir(III) pentamethylcyclopentadienyl catalysts for suppression of this competing pathway is reported. Modulation of the stereoelectronic properties of the auxiliary bidentate ligands to be more electron-donating was suggested by d. functional theory calculations to lower the C-H insertion barrier favoring the desired reaction. These catalysts transform a wide range of 1,4,2-dioxazol-5-ones, carbonylnitrene precursors easily accessible from carboxylic acids, into the corresponding ¦Ã-lactams via sp3 and sp2 C-H amidation with exceptional selectivity. The power of this method was further demonstrated by the late-stage functionalization of amino acid derivatives and other bioactive mols.
Science (Washington, DC, United States) published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Name: 2-Methyl-4-phenylbutanoic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia