Ispizua-Rodriguez, Xanath published the artcileDirect Synthesis of Tri-/Difluoromethyl Ketones from Carboxylic Acids by Cross-Coupling with Acyloxyphosphonium Ions, COA of Formula: C8H7NO4, the publication is Chemistry – A European Journal (2021), 27(64), 15908-15913, database is CAplus and MEDLINE.
A simple and straightforward approach to the synthesis of trifluoromethyl and difluoromethyl ketones RC(O)CF3 [R = naphth-2-yl, benzyl, (Z)-cycloundecen-2-yl, etc.] and RC(O)CF2H from widely available carboxylic acids RC(O)OH is disclosed. The transformation utilizes an acyloxyphosphonium ion as the active electrophile, conveniently generated in situ from the carboxylic acid substrate by using commodity chems. The utility of the reaction system is exemplified by its chemoselectivity, with tolerance to a variety of important functional groups. The late-stage functionalization of carboxylic acid active pharmaceutical ingredients and pharmaceutically relevant compounds is also discussed.
Chemistry – A European Journal published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, COA of Formula: C8H7NO4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia