Le, Ky Khac Anh published the artcile1-Aminopyridinium Ylides as Monodentate Directing Groups for sp3 C-H Bond Functionalization, Recommanded Product: 2-Methyl-4-phenylbutanoic acid, the publication is Journal of the American Chemical Society (2019), 141(37), 14728-14735, database is CAplus and MEDLINE.
1-Aminopyridinium ylides are efficient directing groups for palladium-catalyzed ¦Â-arylation and alkylation of sp3 C-H bonds in carboxylic acid derivatives The efficiency of these directing groups depends on the substitution at the pyridine moiety. The unsubstituted pyridine-derived ylides allow functionalization of primary C-H bonds, while methylene groups are unreactive in the absence of external ligands. 4-Pyrrolidinopyridine-containing ylides are capable of C-H functionalization in acyclic methylene groups in the absence of external ligands, thus rivaling the efficiency of the aminoquinoline directing group. Preliminary mechanistic studies have been performed. A cyclopalladated intermediate has been isolated and characterized by X-ray crystallog., and its reactivity was studied.
Journal of the American Chemical Society published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Recommanded Product: 2-Methyl-4-phenylbutanoic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia