Lee, Sang Ju published the artcileSimple and highly efficient synthesis of 3′-deoxy-3′-[18F]fluorothymidine using nucleophilic fluorination catalyzed by protic solvent, Formula: C17H37NO3, the publication is European Journal of Nuclear Medicine and Molecular Imaging (2007), 34(9), 1406-1409, database is CAplus and MEDLINE.
The aim of this study was to develop a method of radiochem. synthesis of 3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) with an improved radiochem. yield using nucleophilic substitution catalyzed by protic solvent. We introduced t-BuOH as a new reaction solvent for nucleophilic [18F]fluorination with [18F]fluoride using (5′-O-DMTr-2′-deoxy-3′-O-furanosyl-¦Â-D-threo-pentofuranosyl)-3-N-BOC-thymine to synthesize [18F]FLT. [18F]F– was eluted with (1) tetrabutylammonium bicarbonate (TBAHCO3), (2) Cs2CO3 and kryptofix 2.2.2 (K222) after trapping of [18F]F– on an ion exchange cartridge, or (3) addition of tetrabutylammonium hydroxide (TBAOH) and [18F]F– to the reactor without trapping [18F]F– on an ion exchange cartridge. We optimized [18F]fluorination conditions with t-butanol and then applied them to automatic synthesis using com. available radiochem. modules (TracerLab MX, GE Healthcare). We achieved a high radiochem. yield of 85.3 ¡À 3.5% by radio-TLC with TBAHCO3 as an elution solvent and 20 mg of precursor at 100¡ãC (n = 4). With the same labeling conditions, use of Cs2CO3 and K222 with t-BuOH and TBAOH with t-BuOH generated radiochem. yields of 57.1 ¡À 22.5% and 55.0 ¡À 18.8% by radio-TLC, resp. (n = 3 for each condition). Automated synthesis with TBAHCO3 and 20 mg of precursor at 120¡ãC for 10 min of [18F]fluorination led to radiochem. yields of 60.2 ¡À 5.2% after HPLC purification with an MX module (n = 10). Synthesized [18F]FLT was stable for 6 h. [18F]FLT was synthesized with a significantly improved radiochem. yield by nucleophilic substitution catalyzed by protic solvent with mild reaction conditions and a short preparation time.
European Journal of Nuclear Medicine and Molecular Imaging published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Formula: C17H37NO3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia