Lenin, Dandamudi V. published the artcile¦Â-Nitrostyrenes as a valuable precursor for the synthesis of ¦Â-aryl-¦Ã-lactam and 2-oxo-1,2-dihydroquinoline derivatives, Formula: C10H11NO4, the publication is Journal of Heterocyclic Chemistry (2022), 59(3), 588-596, database is CAplus.
Two different reaction pathways for the synthesis of ¦Â-aryl-¦Ã-lactam and 2-oxo-1,2-dihydroquinoline derivatives I (R = H, 2-Cl, 3,4-dimethoxy, 4-Et, etc.) and II (R1 = H, Cl, Br) using ¦Â-nitrostyrenes R2CH=CHNO2 (R2 = Ph, 3,4-dimethoxyphenyl, 2-nitrophenyl, etc.) were successfully demonstrated. The reaction strategy involves the Michael addition followed by reduction and cyclization reactions. Michael adducts containing two different nitro group such as one on aryl ring and another on side chain, selectively take the path to involve nitro group on aryl to form 2-oxo-1,2-dihydroquinoline derivatives II as cyclized product. Michael adducts with nitro group on side chain alone forms ¦Â-aryl-¦Ã-lactam derivatives I as cyclized product. This methodol. is appealing with reliability and scalability with gram scale products that can be synthesized. These heterocyclic compounds can be exploited for their biol. activity.
Journal of Heterocyclic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Formula: C10H11NO4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia