Narobe, Rok published the artcileDecarboxylative Ritter-Type Amination by Cooperative Iodine (I/III)-Boron Lewis Acid Catalysis, Quality Control of 104-03-0, the publication is ACS Catalysis (2022), 12(1), 809-817, database is CAplus.
Recent years have witnessed important progress in synthetic strategies exploiting the reactivity of carbocations via photochem. or electrochem. methods. Yet, most of the developed methods are limited in their scope to certain stabilized positions in mols. Herein, Author report a metal-free system based on the iodine (I/III) catalytic manifold, which gives access to carbenium ion intermediates also on electronically disfavored benzylic positions. The unusually high reactivity of the system stems from a complexation of iodine (III) intermediates with BF3. The synthetic utility of decarboxylative Ritter-type amination protocol has been demonstrated by the functionalization of benzylic as well as aliphatic carboxylic acids, including late-stage modification of different pharmaceutical mols. Notably, the amination of ketoprofen was performed on a gram scale. Detailed mechanistic investigations by kinetic anal. and control experiments suggest two mechanistic pathways.
ACS Catalysis published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Quality Control of 104-03-0.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia