Reis, Joana published the artcileExploring nitrostyrene as a scaffold for a new class a of monoamine oxidase inhibitors, Related Products of catalysis-chemistry, the publication is Letters in Drug Design & Discovery (2012), 9(10), 958-961, database is CAplus.
To find the structural features that are relevant for MAO inhibitory activity and selectivity towards MAO-B isoform, a series of compounds encompassing a ¦Â-nitrostyrene moiety was designed and the in vitro inhibitory activity was evaluated. The synthesis and pharmacol. evaluation of a series of functionalized derivatives of ¦Â-methyl-¦Â-nitrostyrene with distinct substitution patterns in the Ph ring, namely HO, MeO, PhCH2O, and H2CO2 was reported. All the studied compounds were substituted in meta and para positions of the Ph ring related to the nitrovinyl side-chain. The synthesized compounds were evaluated for activity towards both human MAO isoforms, and some of them displayed activities in the low micromolar range. Particularly a methylenedioxy derivative exhibited high potency and selectivity towards MAO-B.
Letters in Drug Design & Discovery published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Related Products of catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia