Siddiqui, Aness Ahmad published the artcileSynthesis, anti-convulsant activity and molecular docking study of novel thiazole pyridazinone hybrid analogues, Related Products of catalysis-chemistry, the publication is Bioorganic Chemistry (2020), 103584, database is CAplus and MEDLINE.
A series of hybrid pyridazinone-thiazoles (I)[R = Ph, p-tolyl, p-anisyl, etc.] connected through amide linkage were designed and synthesized. Among these, compound I [R = p-chlorophenyl] demonstrated significant anticonvulsant activity with median ED of 24.38 mg/kg (MES) and 88.23 mg/kg (scPTz). Results of GABA estimation showed a marked increase in the GABA level when compared with control. Mol. docking studies at the active site of GABA receptor, further confirmed the GABA modulatory effects of I [R = p-chlorophenyl].
Bioorganic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C31H25F2N5O7S, Related Products of catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia