Takeda, Shuichi published the artcileMetabolic fate of triethylenetetramine dihydrochloride (trientine hydrochloride, TJA-250) 1. Absorption, distribution and excretion in rats after single administration of 14C-TJA-250, Category: catalysis-chemistry, the publication is Oyo Yakuri (1995), 49(2), 163-71, database is CAplus.
The absorption, distribution and excretion of radioactivity were investigated in rats after single i.v. or oral administration of 14C-TJA-250 (triethylenetetramine dihydrochloride). Oral administration of 14C-TJA-250 at a dose of 25 mg/kg produced a maximal plasma concentration (Cmax) at 1 h, after which the plasma level fell with half lives of 1.69 and 30.35 h. When the same dose was given i.v., the radioactivity rose to the maximum level at 30 min after administration and then the level fell with a half life of 1.27 h up to 6 h. The AUC (area under the curve) values after i.v. and oral administration were 74.67 and 33.05 ¦Ìg eq. * hr/mL, resp. and the extent of absorption after oral dose was 44.3%. The Cmax and AUC obtained from rats not in a fasting state corresponded to 73.9 and 86.2%, resp., of the values in rats in a fasting state. There was a dose-dependent increase in Cmax and AUC after oral administration of 10 to 62.5 mg/kg. Sex difference was observed in plasma radioactivity concentration Within 168 h after single intraveonus and oral administration, 95.40 and 39.80%, resp., of dose was excreted into urine; 3.26 and 58.34%, resp., into feces; and 0.62 and 0.69%, resp., into expired air. Biliary excretion was only 0.86% of dose within 48 h and 1 h after oral administration. High radioactivity was found mainly in kidney and liver. No definite accumulation of radioactivity occurred in any tissues 168 h after administration. The distribution of radioactivity after i.v. administration was similar to that after oral dosing.
Oyo Yakuri published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C10H10N2, Category: catalysis-chemistry.
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https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia