Takeda, Shuichi published the artcileMetabolic fate of triethylenetetramine dihydrochloride (trientine hydrochloride, TJA-250) 3. Bioavailability of TJA-250 in rats after single administration, Application of N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Oyo Yakuri (1995), 49(2), 179-86, database is CAplus.
A study was made with respect to the bioavailability of TJA-250 (triethylenetetramine dihydrochloride) in rats after single i.v. and oral administration. The plasma concentration was determined by HPLC with fluorescence detection; TJA-250 was labeled with fluorescamine before injection. The plasma concentration of TJA-250 rapidly fell with a half life of 0.54 and 0.65 h after i.v. administration at doses of 5 and 25 mg/kg, resp. In rats in a fasting state and those not in a fasting state, oral administration of 25 mg/kg of TJA-250 produced maximal plasma concentrations of 0.5 h, after which the plasma concentrations fell with a half life of 0.97 and of 1.57 h, resp. The bioavailability was 25.5% in rats in a fasting state and 14.0% in rats not in a fasting state. After intraduodenal administration of the same dose, the AUC was larger than that after oral administration. The effects of various factors, e.g. metal ions, laboratory chow and concentration of TJA-250 in a dosage solution on the absorption of TJA-250 from gut were studied by the in situ loop technique in rats. The absorption was affected by the concentration of dosage solution in a concentration-dependent manner. Liver perfusion study showed a poor metabolism of TJA-250. These results indicate that the concentration of dosage solution and first pass metabolism in intestinal wall may play an important role in the absorption of TJA-250 in humans as well as in rats.
Oyo Yakuri published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C4H7BrO2, Application of N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia