Canonica, L. published the artcileThe hypocholesterolemic action of some synthetic compounds, SDS of cas: 1949-41-3, the publication is Drugs Affecting Lipid Metab., Proc. Symp., Milan (1961), 328-35, database is CAplus.
The anti-cholesterolemic effect of some phenylsubstituted aliphatic carboxylic acids was examined by their effect on the hyper-cholesterolemia induced in rats by intraperitoneal injection of 500 mg./kg. of Triton WR 1339, blood cholesterol being determined 22 hrs. after injection by Bloor’s method and the effect evaluated statistically. Toxicity of the compounds in mice and the min. dose giving a significant reduction in blood cholesterol were determined Thirty-four compounds were synthesized and tested; these were in 6 groups in which a phenyl group was introduced in various positions along an aliphatic C chain. The groups were: butyric acids; valeric and isovaleric acids; methylbutyric acids; unsaturated acids with isoprenoid structures; diand tetrahydrogeranic acids; and mevalonic acids. Among ¦Á-phenylbutyric acids, para substitution of OH and NH2 resulted in inactive compounds whereas the p-Cl, -Me, and -OMe compounds were active. Phenyltetrahydrogeranic acid and phenylmevalonic acid derivatives were inactive. Phenyl derivatives of C5 acids with a branched chain were active, particularly ¦Â-benzylidenebutyric (I), ¦Á-methyl-¦Ã-phenylbutyric (II), ¦Á-benzylbutyric (III), ¦Á-phenyldimethylacrylic (IV), and ¦Â-phenylisovaleric (V) acids. The L.D.50 (mice mg./kg.), min. effective dose (mg./kg.), and therapeutic index of these were: I, 520, 130, 4; II, 712, 71, 10; III, 1068, 215, 4; IV, 1700, 340, 5; V, 1550, 387, 4. The only active straight-chain compound was ¦Â-phenylvaleric acid (748, 249, 3).. Biosynthesis of fatty acids from acetate-1-C14 was inhibited by I, IV, and V to varying degrees; cholesterol synthesis was similarly inhibited by I and cholesterol synthesis from mevalonate-2-C14 was inhibited by all except II. The anticholestcrolemic effect of I was confirmed clin. with doses of 200 mg./day.
Drugs Affecting Lipid Metab., Proc. Symp., Milan published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, SDS of cas: 1949-41-3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia