Cho, Inha published the artcileEnantioselective aminohydroxylation of styrenyl olefins catalyzed by an engineered hemoprotein, HPLC of Formula: 1293990-73-4, the publication is Angewandte Chemie, International Edition (2019), 58(10), 3138-3142, database is CAplus and MEDLINE.
Chiral 1,2-amino alcs. are widely represented in biol. active compounds from neurotransmitters to antivirals. While many synthetic methods have been developed for accessing amino alcs., the direct aminohydroxylation of alkenes to unprotected, enantio-enriched amino alcs. remains a challenge. Using directed evolution, we have engineered a hemoprotein biocatalyst based on a thermostable cytochrome c that directly transforms alkenes to amino alcs. with high enantioselectivity (up to 2500 TTN and 90 % ee) under anaerobic conditions with O-pivaloylhydroxylamine as an aminating reagent. The reaction is proposed to proceed via a reactive iron-nitrogen species generated in the enzyme active site, enabling tuning of the catalyst’s activity and selectivity by protein engineering.
Angewandte Chemie, International Edition published new progress about 1293990-73-4. 1293990-73-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is O-Pivaloylhydroxylamine trifluoromethanesulfonate, and the molecular formula is C6H12F3NO5S, HPLC of Formula: 1293990-73-4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia