Hopewell, Robert published the artcileA simplified radiosynthesis of [18F]MK-6240 for tau PET imaging, HPLC of Formula: 17351-61-0, the publication is Journal of Labelled Compounds and Radiopharmaceuticals (2019), 62(2), 109-114, database is CAplus and MEDLINE.
[18F]MK-6240 (6-(fluoro)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine, I) is a highly selective PET radiotracer for the in vivo imaging of neurofibrillary tangles (NFTs). [18F]MK-6240 was synthesized in one step from its bis-Boc protected precursor tert-Bu N-[(tert-butoxy)carbonyl]-N-(6-nitro-3-[1H-pyrrolo[2,3-c]pyridin-1-yl]isoquinolin-5-yl)carbamate in DMSO using [18F] fluoride with TEA HCO3 with step-wise heating up to 150¡ãC, resulting in an isolated radiochem. yield of 9.8% ¡À 1.8% (n = 3) calculated from the end of bombardment (5.2% ¡À 1.0% calculated from the end of synthesis). This new synthetic approach eliminates the acidic deprotection of the bis-Boc 18F-labeled intermediate, which reduces the number of operations necessary for the synthesis as well as losses, which occur during deprotection and neutralization of the crude product mixture prior to the HPLC purification The synthesis was performed automatically with a single-use cassette on an IBA Synthera+ synthesis module. This synthesis method affords the radioligand with a reliable radiochem. yield, high radiochem. purity, and a high molar activity. [18F]MK-6240 synthesized with this method has been regularly (n > 60) used in our ongoing human and animal PET imaging studies.
Journal of Labelled Compounds and Radiopharmaceuticals published new progress about 17351-61-0. 17351-61-0 belongs to catalysis-chemistry, auxiliary class Phase Transfer Catalyst, name is Tetraethylammonium hydrogencarbonate, and the molecular formula is C9H21NO3, HPLC of Formula: 17351-61-0.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia