Light, B. published the artcileThe effect of triethylenetetramine dihydrochloride on the in vivo susceptibility of Pseudomonas aeruginosa to gentamicin, Category: catalysis-chemistry, the publication is Journal of Antibiotics (1979), 32(8), 834-8, database is CAplus and MEDLINE.
Triethylenetetramine-2HCl (I) [38260-01-4] increased the efficacy of gentamicin [1403-66-3] in vivo against a clin. isolate of P. aeruginosa, designated Ps 15. Mice which were inoculated with 10 x LD50 of Ps 15 and treated with doses of 2?16 mg of gentamicin/kg/day all died. However, treatment with 8 mg of gentamicin/kg/day plus 30 mg I/day markedly reduced the mortality. The combined therapy also reduced the number of viable organisms that accumulated in the kidney during a 24-h period post inoculation. When a dosage level of 8 mg of gentamicin was exceeded in the combined treatment regimen, all of the infected mice died, and a high concentration of endotoxin could be detected in the mouse sera by the limulus assay.
Journal of Antibiotics published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Category: catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia