Murafuji, Hidenobu published the artcileDiscovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors, Application In Synthesis of 6084-58-8, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(23), 5272-5276, database is CAplus and MEDLINE.
Compound I, composed of a 1,3,6-trisubstituted 1,4-diazepane-7-one, was discovered as a novel human kallikrein 7 (KLK7, stratum corneum chymotryptic enzyme, SCCE) inhibitor, and its derivatives were synthesized and evaluated. Structure-activity relationship studies of the amidoxime unit and benzoic acid part of this new scaffold led to the identification of compounds II (R = CO2H and R = Ms), which were more potent than the hit compound, I. The X-ray co-crystal structure of compound II (R = CO2H) and human KLK7 revealed the characteristic interactions and enabled explanations of the structure-activity relationship.
Bioorganic & Medicinal Chemistry Letters published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Application In Synthesis of 6084-58-8.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia