Nandy, Saikat published the artcileThe possibility of a fully automated procedure for radiosynthesis of fluorine-18-labeled fluoromisonidazole using a simplified single, neutral alumina column purification procedure, Name: Tetrabutylammonium hydrogencarbonate, the publication is Applied Radiation and Isotopes (2010), 68(10), 1937-1943, database is CAplus and MEDLINE.
A novel fully automated radiosynthesis procedure for [18F]Fluoromisonidazole using a simple alumina cartridge-column for purification instead of conventionally used semi-preparative HPLC was developed. [18F]FMISO was prepared via a one-pot, two-step synthesis procedure using a modified nuclear interface synthesis module. Nucleophilic fluorination of the precursor mol. 1-(2′-nitro-1′-imidazolyl)-2-O-tetrahydropyranyl-3-O-toluenesulfonylpropanediol (NITTP) with no-carrier added [18F]fluoride followed by hydrolysis of the protecting group with 1 M HCl. Purification was carried out using a single neutral alumina cartridge-column instead of semi-preparative HPLC. The maximum overall radiochem. yield obtained was 37.49¡À1.68% with 10 mg NITTP (n=3, without any decay correction) and the total synthesis time was 40¡À1 min. The radiochem. purity was greater than 95% and the product was devoid of other chem. impurities including residual aluminum and acetonitrile. The biodistribution study in fibrosarcoma tumor model showed maximum uptake in tumor, 2 h post injection. Finally, PET/CT imaging studies in normal healthy rabbit, showed clear uptake in the organs involved in the metabolic process of MISO. No bone uptake was observed excluding the presence of free [18F]fluoride. The reported method can be easily adapted in any com. FDG synthesis module.
Applied Radiation and Isotopes published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Name: Tetrabutylammonium hydrogencarbonate.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia