Nishihata, Toshiaki published the artcileIntestinal absorption of N,N’-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulfonate in rats, Synthetic Route of 71079-09-9, the publication is Chemical & Pharmaceutical Bulletin (1988), 36(7), 2544-50, database is CAplus and MEDLINE.
The intestinal absorption of N,N‘-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulfonate (FOY305) in rats was investigated using a rat intestinal loop method. Plasma drug concentrations and the disappearance of the drug from the intestinal lumen were measured. The absorption of FOY305 after administration into a rectal loop was greater than those after administration into variously positioned small intestinal loops. The low absorption of FOY305 after administration into the small intestine was due to the rapid degradation of FOY305 by esterase activity in the small intestinal lumen. The results are discussed with respect to the development of an oral or rectal dosage form of FOY305.
Chemical & Pharmaceutical Bulletin published new progress about 71079-09-9. 71079-09-9 belongs to catalysis-chemistry, auxiliary class Salt,Carboxylic acid,Carbamidine,Amine,Benzene,Ester,Protease,Ser/Thr Protease, name is 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt, and the molecular formula is C17H19N3O7S, Synthetic Route of 71079-09-9.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia