Rahmani-Nezhad, Samira published the artcileSynthesis, in vitro cytotoxicity and apoptosis inducing study of 2-aryl-3-nitro-2H-chromene derivatives as potent anti-breast cancer agents, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is European Journal of Medicinal Chemistry (2014), 562-569, database is CAplus and MEDLINE.
A series of 2-aryl-3-nitro-2H-chromenes I [R1 = H, OMe; R2 = H, OMe; R3 = H, OMe; R4 = 4-OMe, 3,4-dimethyoxy, 4-Cl, etc.] were designed as hybrid analogs of flavanone, ¦Â-nitrostyrene and nitrovinylstilbene scaffolds. They were synthesized from the reaction of appropriate ¦Â-nitrostyrenes and salicylaldehydes in good yields. In vitro cytotoxic activities of compounds I were tested against breast cancer cell lines including MCF-7, T-47D and MDA-MB-231. Most compounds exhibited good cytotoxic activity against selected cell lines, being more potent than standard drug etoposide. Representatively, 8-methoxy-3-nitro-2-(4-chlorophenyl)-2H-chromene I (R1=R2=H, R3=OMe, R4= 4-Cl) with IC50 = 0.2 ¦ÌM against MCF-7 cells, was 36-times more potent than etoposide. Apoptosis as a mechanism of cell death for selected compounds I (R1=R2=H, R3=R4=OMe) and I (R1=R2=H, R3=OMe, R4= 4-Cl) was confirmed morphol. by acridine orange/ethidium bromide double staining and TUNEL anal., as well as caspase-3 activation assay.
European Journal of Medicinal Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia