Aziz, I. published the artcileSynthesis, Characterization, DNA Interaction Study, Antibacterial and Anticancer Activities of New Palladium(II) Phosphine Complexes, Category: catalysis-chemistry, the publication is Russian Journal of General Chemistry (2018), 88(3), 551-559, database is CAplus.
Palladium(II) complexes with N,N-dimethylthiourea and phosphines [tri-p-tolylphosphine (Tptp), benzyl(diphenyl)phosphine (Bdp), cyclohexyl(diphenyl)phosphine (Cdp)] were synthesized by the direct reaction of K2[(PdCl4)] with the corresponding phosphines and then with N,N-dimethylthiourea at a molar ratio of 1:2:2, resp. The general formula of these complexes is [Pd(L1)2(L2)2]Cl2, where L1 = N,N-dimethylthiourea (Dmtu), L2 = Tptp, Bdp, Cdp. The complexes were characterized by elemental analyses, multinuclear NMR (1H, 13C, 31P), and FTIR. The complex with cyclohexyl(diphenyl)phosphine was also characterized by single crystal x-ray anal. The spectral and crystallog. data suggest monodentate coordination of dimethylthiourea through the S atom and of the phosphine ligand through the P atom and distorted square planar environment of Pd(II). The synthesized complexes were screened for DNA binding, antibacterial, cytotoxic, and antitumor activities. The complexes show interaction with DNA via intercalative mode. The complexes show good activity against both gram pos. and gram neg. bacteria as compared to that of a standard drug, Imipenem. Their antitumor activity against MCF7 tumor cell line is comparable with doxorubicin. MTT assay was used to study the cytotoxicity of the studied compounds
Russian Journal of General Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Category: catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia