Giessel, Josephine M. published the artcileSubstituted cinnamic anhydrides act as selective inhibitors of acetylcholinesterase, Formula: C9H7NO4, the publication is Bioorganic Chemistry (2019), 103058, database is CAplus and MEDLINE.
Cinnamic anhydrides have been shown to be more than reactive reagents, but they also act as inhibitors of the enzyme acetylcholinesterease (AChE). Thus, out of a set of 33 synthesized derivatives, several of them were mixed type inhibitors for AChE (from elec. eel). Thus, (E)-3-(2,4-dimethoxyphenyl)acrylic anhydride (2c) showed Ki = 8.30 ¡À 0.94 ¦ÌM and Ki‘ = 9.54 ¡À 0.38 ¦ÌM, and for (E)-3-(3-chlorophenyl)acrylic anhydride (2u) Ki = 8.23 ¡À 0.93 ¦ÌM and Ki‘ = 13.07 ¡À 0.46 ¦ÌM were measured. While being not cytotoxic to many human cell lines, these compounds showed an unprecedented and noteworthy inhibitory effect for AChE but not for butyrylcholinesterase (BChE).
Bioorganic Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Formula: C9H7NO4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia