Goeke, B. published the artcileEffect of a specific serine protease inhibitor on the rat pancreas: systemic administration of camostat and exocrine pancreatic secretion, HPLC of Formula: 71079-09-9, the publication is Digestion (1984), 30(3), 171-8, database is CAplus and MEDLINE.
Camostat??[59721-28-7], a synthetic serine?protease??[37259-58-8] inhibitor, specifically inhibits the trypsin??[9002-07-7] activity in vitro. Immediately after i.v. administration of camostat (5, 2.5, 0.5, and 0.1 mg/kg/h) the trypsin activity in the biliary-pancreatic juice was diminished dose-dependently in anesthetized rats. Amylase??[9000-92-4] release was not influenced. Camostat and its metabolites were detected by high-pressure liquid chromatog. in the pancreatic juice and tissue; in plasma, only the metabolites were found. Therefore, the inhibitory action of camostat on the trypsin activity in the biliary-pancreatic juice may be due to penetration of camostat into the juice.
Digestion published new progress about 71079-09-9. 71079-09-9 belongs to catalysis-chemistry, auxiliary class Salt,Carboxylic acid,Carbamidine,Amine,Benzene,Ester,Protease,Ser/Thr Protease, name is 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt, and the molecular formula is C17H19N3O7S, HPLC of Formula: 71079-09-9.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia