Kupriyanova, Olga V. published the artcilePotential of chromatography and mass spectrometry for the differentiation of three series of positional isomers of 2-(dimethoxyphenyl)-N-(2-halogenobenzyl)ethanamines, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Drug Testing and Analysis (2022), 14(6), 1102-1115, database is CAplus and MEDLINE.
N-(2-substituted benzyl)-2,5-dimethoxyphenethylamines often cause severe poisonings which has led to their legal prohibition in many countries. At the same time, their positional isomers can be studied as potential therapeutic drugs. In this regard, the search for various approaches to differentiate these isomers is an important practical task, the solution of which would guarantee from identification errors during laboratory anal. In this paper, the possibilities of differentiation of isomers varying in the position of two methoxy groups in the phenylethyl part of the mol. are considered on the example of compounds of NBF, NBCl, and NBBr series by chromatog.-mass spectrometry methods. Gas or liquid reverse-phase chromatog. in the proposed chromatog. separation modes has demonstrated their ability to resolve this problem reliably. Data on retention indexes of isomeric compounds and their derivatives can serve as an addnl. identification criterion for gas chromatog.-mass spectrometry (GC-MS) anal. Differentiation of NBF and NBCl isomers using electron ionization (EI) mass spectra is feasible only if both the spectrum of the compound and its N-trifluoroacetyl derivative are registered; differentiation of NBBr positional isomers under these conditions does not require obtaining the derivatives Using electrospray ion source, the compounds can easily be differentiated based on the distinctive features of their collision induced dissociation (CID) spectra recorded at low energy values, which also does not require the synthesis of derivatives The data presented in current paper will be useful for anal. in laboratories providing the determination of narcotic drugs.
Drug Testing and Analysis published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Name: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia