McCoy, Michael A. published the artcileBiophysical Survey of Small-Molecule ¦Â-Catenin Inhibitors: A Cautionary Tale, Name: Fmoc-Pro-OH, the publication is Journal of Medicinal Chemistry (2022), 65(10), 7246-7261, database is CAplus and MEDLINE.
The canonical Wingless-related integration site signaling pathway plays a critical role in human physiol., and its dysregulation can lead to an array of diseases. ¦Â-Catenin is a multifunctional protein within this pathway and an attractive yet challenging therapeutic target, most notably in oncol. This has stimulated the search for potent small-mol. inhibitors binding directly to the ¦Â-catenin surface to inhibit its protein-protein interactions and downstream signaling. Here, we provide an account of the claimed (and some putative) small-mol. ligands of ¦Â-catenin from the literature. Through in silico anal., we show that most of these mols. contain promiscuous chem. substructures notorious for interfering with screening assays. Finally, and in line with this anal., we demonstrate using orthogonal biophys. techniques that none of the examined small mols. bind at the surface of ¦Â-catenin. While shedding doubts on their reported mode of action, this study also reaffirms ¦Â-catenin as a prominent target in drug discovery.
Journal of Medicinal Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Name: Fmoc-Pro-OH.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia