Randall, William C.’s team published research in Journal of Medicinal Chemistry in 22 | CAS: 1798-04-5

Journal of Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Related Products of catalysis-chemistry.

Randall, William C. published the artcileQuantitative structure-activity relationships involving the inhibition of glycolic acid oxidase by derivatives of glycolic and glyoxylic acids, Related Products of catalysis-chemistry, the publication is Journal of Medicinal Chemistry (1979), 22(6), 608-13, database is CAplus and MEDLINE.

Seventy substituted glycolic, oxyacetic, and glyoxylic acids [RCH(OH)CO2H, RCOCO2H, and ROCH2CO2H where R = alkyl, substituted alkyl, Ph, aryl, or substituted aryl] including 6 new glycolic and glyoxylic acids were investigated as inhibitors of glycolate oxidase [9028-71-1], an enzyme involved in the metabolic production of oxalate. Such inhibitors are important in the treatment of genetic hyperoxalurias, diseases in which the overproduction of oxalate leads to systemic deposits of CaC2O4. Regression anal. and quant. structure-activity relations were used. The best overall correlation with inhibition was with the Hansch parameter ¦Ð.

Journal of Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia