Ye, Chen-Xi published the artcileStereocontrolled 1,3-nitrogen migration to access chiral ¦Á-amino acids, COA of Formula: C8H7NO4, the publication is Nature Chemistry (2022), 14(5), 566-573, database is CAplus and MEDLINE.
Here a protocol for the economical and practical synthesis of optically active ¦Á-amino acids RNHC(R1)(R2)C(O)OH (R = Ts, Ms, C(O)OMe, (2,2,2-trichloroethoxy)carbonyl; R1 = H, Me; R2 = pent-2-yn-1-yl, 4-methylphenyl, 2H-1,3-benzodioxol-5-yl, etc.) based on an unprecedented stereocontrolled 1,3-nitrogen shift was reported. The method employs abundant and easily accessible carboxylic acids R1CH(R2)C(O)OH as starting materials, which are first connected to a nitrogenation reagent, followed by a highly regio- and enantioselective ruthenium- or iron-catalyzed C(sp3)-H amination. This straightforward method displays a very broad scope, providing rapid access to optically active ¦Á-amino acids with aryl, allyl, propargyl and alkyl side chains, and also permits stereocontrolled late-stage amination of carboxylic-acid-containing drugs and natural products.
Nature Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C14H21BO2, COA of Formula: C8H7NO4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia