Borowiecki, Pawel published the artcileBiocatalytic Asymmetric Reduction of ¦Ã-Keto Esters to Access Optically Active ¦Ã-Aryl-¦Ã-butyrolactones, Application of 3-Benzoylpropionicacid, the publication is Advanced Synthesis & Catalysis (2020), 362(10), 2012-2029, database is CAplus.
An efficient stereoselective syntheses of a series of functionalized optically active ¦Ã-aryl-¦Ã-butyrolactones is achieved by enzymic asym. reduction of the corresponding sterically demanding ¦Ã-keto esters employing wild-type and recombinant alc. dehydrogenases. The best stereoselectivities for the reduction via hydrogen transfer was obtained with two short chain dehydrogenases (SDRs) of complementary stereospecificity from Aromatoleum aromaticum, namely the Prelog-specific NADH-dependent (S)-1-phenylethanol dehydrogenase [(S)-PED] and the anti-Prelog-specific (R)-1-(4-hydroxyphenyl)-ethanol dehydrogenase [(R)-HPED], resp. Biotransformations catalyzed by both enzymes, followed by TFA-catalyzed cyclization of the resulting ¦Ã-hydroxy esters, furnished the resp. (S)- and (R)-configured products with exquisite optical purity (up to >99% ee). The synthetic value was demonstrated on preparative scale for the asym. bioreduction of the model compound, Me 4-oxo-4-phenylbutanoate, affording optically pure (S)-¦Ã-phenyl-¦Ã-butyrolactone (>99% ee) in 67-74% isolated yield at 89-95% conversion depending on the applied scale.
Advanced Synthesis & Catalysis published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Application of 3-Benzoylpropionicacid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia