Deng, Yu published the artcileSemi-synthesis, antibacterial activity, and molecular docking study of novel pleuromutilin derivatives bearing cinnamic acids moieties, Application of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Archiv der Pharmazie (Weinheim, Germany) (2019), 352(1), n/a, database is CAplus and MEDLINE.
To develop new antibiotics owning a special mechanism, we used the mol. assembly method to synthesize a series of novel pleuromutilin derivatives containing a cinnamic acid scaffold at the C-14 side chain. We evaluated their antibacterial activity and used in silico mol. docking to study their binding mode with the target. The structure-activity relationship (SAR) study suggested that compounds with NO2 (13e), OH (13u), and NH2 (13y) appeared more active (0.0625-2 ¦Ìg/mL) in vitro against several penicillin-resistant Gram-pos. bacteria and the position of the substituent on the benzene ring would affect the activity. The in vivo efficacy investigation of 13e, 13u, and 13y with once daily intragastric (i.g.) administration at 40 mg/kg for 3 consecutive days in a mouse systemic infection model showed that 13u had equal activity as valnemulin providing the mice with 60% survival, while 13e and 13y gave 30 and 40% survival, resp. The mol. docking studies indicated that ¦Ð-¦Ð stacking and hydrogen bond formation played important roles in improving the antibacterial activity.
Archiv der Pharmazie (Weinheim, Germany) published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Application of (E)-3-(3-Nitrophenyl)acrylic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia