Dewangan, Rikeshwer Prasad published the artcileSpermine-conjugated short proline-rich lipopeptides as broad-spectrum intracellular targeting antibacterial agents, Synthetic Route of 71989-31-6, the publication is Journal of Medicinal Chemistry (2022), 65(7), 5433-5448, database is CAplus and MEDLINE.
Toward the design of new proline-rich peptidomimetics, a short peptide segment, present in several proline-rich antimicrobial peptides (AMPs), was selected. Fatty acids of varying lengths and spermine were conjugated at the N- and C-terminals of the peptide, resp. Spermine-conjugated lipopeptides, C10-PR-Spn and C12-PR-Spn, exhibited min. inhibitory concentrations within 1.5-6.2¦ÌM against the tested pathogens including resistant bacteria and insignificant hemolytic activity against human red blood cells up to 100¦ÌM concentrations and demonstrated resistance against trypsin digestion. C10-PR-Spn and C12-PR-Spn showed synergistic antimicrobial activity against multidrug-resistant methicillin-resistant Staphylococcus aureus with several tested antibiotics. These lipopeptides did not permeabilize bacterial membrane-mimetic lipid vesicles or damage the Escherichia coli membrane like the nonmembrane-lytic AMP, buforin-II. The results suggested that C10-PR-Spn and C12-PR-Spn could interact with the 70S ribosome of E. coli and inhibit its protein synthesis. C10-PR-Spn and C12-PR-Spn demonstrated superior clearance of bacteria from the spleen, liver, and kidneys of mice, infected with S. aureus ATCC 25923 compared to levofloxacin.
Journal of Medicinal Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Synthetic Route of 71989-31-6.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia