Huang, Tzou-Chi published the artcileDiallyl disulphide, but not diallyl sulphide, increases leucocyte function-associated antigen-1 expression and cellular adhesion in monocytes, Quality Control of 6972-05-0, the publication is Food Chemistry (2010), 120(1), 113-120, database is CAplus.
A steam distillation process at pH 9 was conducted to prepare garlic oil for food supplement. A garlic oil predominant in bioactive diallyl monosulfide (8.9%), diallyl disulfide (56.9%) diallyl trisulfide (7.6%) and diallyl tetrasulfide (2.6%) was obtained from peeled garlic cloves. The adhesion mol. leukocyte function-associated antigen-1 (LFA-1) mediates leukocyte adhesion and migration during immune responses. In this study, we investigated the effects of diallyl sulfide (DAS) and diallyl disulfide (DADS) on LFA-1 expression, cell adhesion and migration in the U937 and peritoneal macrophages from mice. After treatment, DADS, but not DAS, elevated the expression of LFA-1 in a dose- and time-dependent manner in U937 cells and peritoneal macrophages. Moreover, LFA-1 and intracellular adhesion mol.-1 (ICAM-1)-mediated adhesion also was increased by DADS in a dose- and time-dependent manner. After DADS treatment, LFA-1 clustering also increased on U937 surface. In contrast, there was no significant difference in migration of U937 cells between DADS treatment and no treatment. This study indicates the DADS, but not DAS, regulates immune responses by modulating LFA-1 expression, clustering and LFA-1-mediated adhesion in monocytes, evidences that DADS acts as an immune regulator of adhesion mols. during immune responses.
Food Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Quality Control of 6972-05-0.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia