Kondo, Naoya's team published research in Journal of Controlled Release in 220

Kondo, Naoya published the artcileDevelopment of PEGylated peptide probes conjugated with ¹⁸F-labeled BODIPY for PET/optical imaging of MT1-MMP activity, Formula: C17H37NO3, the publication is Journal of Controlled Release (2015), 220(Part_A), 476-483, database is CAplus and MEDLINE.

Since the processing activity of the matrix metalloproteinase MT1-MMP regulates various cellular functions such as motility, invasion, growth, differentiation and apoptosis, precise in vivo evaluation of MT1-MMP activity in cancers can provide beneficial information for both basic and clin. studies. For this purpose, we designed a cleavable Positron Emission Tomog. (PET)/optical imaging probe consisting of BODIPY650/665 and polyethylene glycol (PEG) conjugated to opposite ends of MT1-MMP substrate peptides. We used in vitro and in vivo fluorescence experiments to select suitable substrate peptide sequences and PEG sizes for the MT1-MMP probes and obtained an optimized structure referred to here as MBP-2k. Radiofluorinated MBP-2k ([¹⁸F]MBP-2k) was then successfully synthesized via an ¹⁸F-¹⁹F isotopic exchange reaction in BODIPY650/665. After i.v. injection into mice with xenografted tumors, [¹⁸F]MBP-2k showed significantly higher accumulation in HT1080 tumors with high MT1-MMP activity than in A549 tumors that have low MT1-MMP activity. Moreover, PET images showed better contrast in HT1080 tumors. These results show that [¹⁸F]MBP-2k can be used as a hybrid PET/optical imaging agent and is a promising probe for non-invasive monitoring of MT1-MMP activity in cancers. This probe may also efficiently combine targeted tumor imaging with image-guided surgery that could be beneficial for patients in the future.

Journal of Controlled Release published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Formula: C17H37NO3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia