Otsuki, Makoto published the artcileTherapeutic effects of camostat on caerulein-induced acute pancreatitis in rats, Application In Synthesis of 71079-09-9, the publication is Biomedical Research (1989), 10(Suppl. 1), 25-31, database is CAplus.
Acute pancreatitis was induced in rats by 4 s.c. injections of caerulein (20 ¦Ìg/kg) at hourly intervals. The animals were then given either 100 mg camostat/kg or 0.05M phosphate buffer via gastric tube 30 min after the last caerulein injection. The elevation of serum amylase activity in rats treated with caerulein was reduced by camostat treatment, and the peak value was seen 1 h earlier than that in the rats that did not receive camostat. This was accompanied by an alleviation of the histol. signs of acute pancreatitis, such as cellular infiltration and acinar cell vacuolization. After oral administration, camostat and its metabolite 4-(4-guanidinobenzoyloxy)phenylacetic acid were detectable in plasma for >6 h in concentrations high enough to have antiprotease activity. In addition, camostat stimulated endogenous secretin release. Oral administration of camostat may reduce the severity of caerulein-induced pancreatitis by releasing endogenous secretin and by its antiprotease activity.
Biomedical Research published new progress about 71079-09-9. 71079-09-9 belongs to catalysis-chemistry, auxiliary class Salt,Carboxylic acid,Carbamidine,Amine,Benzene,Ester,Protease,Ser/Thr Protease, name is 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt, and the molecular formula is C17H19N3O7S, Application In Synthesis of 71079-09-9.
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https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia