Shi, Yongjie published the artcileDirect Synthesis of Chiral NH Lactams via Ru-Catalyzed Asymmetric Reductive Amination/Cyclization Cascade of Keto Acids/Esters, Safety of 3-Benzoylpropionicacid, the publication is Organic Letters (2020), 22(7), 2707-2713, database is CAplus and MEDLINE.
A broadly applicable synthesis of enantioenriched NH lactams e.g., I through a one-pot asym. reductive amination/cyclization sequence of easily available keto acids/esters e.g., C6H5C(O)(CH2)2C(O)OMe was reported. Such cascade processes alleviate the demand for protecting group manipulations as well as intermediate purification This strategy is capable of constructing enantioenriched lactams e.g., I in generally high yield and with excellent enantioselectivities (up to 97% ee). Scalable and concise syntheses of key drug intermediates have further displayed the importance of this methodol.
Organic Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C3H5F3O, Safety of 3-Benzoylpropionicacid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia