Cheng, Xiu-Fen published the artcilePalladium(II)-Catalyzed C(sp2)-H Bond Activation/C-N Bond Cleavage Annulation of N-Methoxy Amides and Arynes, Application In Synthesis of 104-03-0, the publication is Organic Letters (2022), 24(11), 2087-2092, database is CAplus and MEDLINE.
The Pd(II)-catalyzed C-H bond activation/C-N bond cleavage annulation reaction of N-alkyoxyamide aryne was developed to synthesize 9,10-dihydrophenanthrenone derivatives I [R1 = H, 3-Me, 2-MeO, etc.; R2 = Me, n-Pr, i-Pr, n-Bu, Ph, cyclohexyl; R3 = Me, n-Bu, Ph; R4 = H, 7-F, 6,7-di-MeO, etc.; R2R3 = (CH2)4, (CH2)5, (CH2)2O(CH2)2]. This reaction exhibited good functional group compatibility with yields up to 92%. Detailed mechanistic studies showed that the key to C-N bond cleavage was the formed eight-membered palladacycle intermediate undergoing nucleophilic addition to the carbonyl group, which provided a new and practical way for N-alkoxyamide directed C-H bond activation.
Organic Letters published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Application In Synthesis of 104-03-0.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia